Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation disease GWASDB TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. 17804836 2007
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease MGD Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis. 26195802 2015
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease MGD Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders. 15366373 2004
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease MGD Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease. 18439426 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease MGD Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. 10204494 1999
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease MGD Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis. 29618659 2018
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease MGD Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. 12486099 2002
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease MGD High fat diet accelerates pathogenesis of murine Crohn's disease-like ileitis independently of obesity. 23977107 2013
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation disease LHGDN Rheumatoid arthritis patients showed high TNFalpha mRNA expression (1.33-fold). 18797411 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation disease LHGDN Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution? 16446172 2006
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease LHGDN BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility. 18381799 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression disease LHGDN Expression of TNF-alpha, tristetraprolin, T-cell intracellular antigen-1 and Hu antigen R genes in synovium of patients with rheumatoid arthritis. 16820934 2006
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation disease LHGDN Tumor necrosis factor-alpha -308 promoter polymorphism contributes independently to HLA alleles in the severity of rheumatoid arthritis in Mexicans. 15725578 2005
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression disease LHGDN Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor. 18668547 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease LHGDN [Role of TNF-alpha and cytokines in the physiopathology of rheumatoid arthritis. Therapeutic perspectives]. 14979058 2003
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease LHGDN Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. 19017992 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation disease LHGDN Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population. 17562093 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation disease LHGDN Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis. 17343250 2007
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression disease LHGDN JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-alpha. 16936264 2006
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease LHGDN Overlapping gene expression profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines interleukin-1 beta and tumor necrosis factor. 15723199 2005
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression disease LHGDN Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression. 16564576 2006
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease LHGDN A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death. 16751383 2006
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation disease LHGDN Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-alpha, IL-1beta, and IL-1Ra genes. 11838837 2002
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease LHGDN The effect of HLA-DR on susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor necrosis factor haplotype. 12528108 2003
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease LHGDN Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cells. 16569263 2006